Fmoc-Aad(OtBu)-OH CAS 159751-47-0

TNN Development Limited yog ib lub tuam txhab txhim khu kev qha thiab cov chaw muag khoom ntawm fmoc-aad(otbu)-oh cas 159751-47-0 hauv Suav teb. Thov koj xav tias dawb rau cov lag luam wholesale customized fmoc-aad(otbu)-oh cas 159751-47-0 ntawm tus nqi qis los ntawm peb lub hoobkas. Yog tias koj muaj lus nug txog cov qauv dawb thiab cov ntaub ntawv luv nqi, thov koj xa email rau peb.

 

 

 

 

 

Fmoc-Aad(OtBu)-OH (CAS: 159751-47-}0) yog ib qho zoo heev thiab ua haujlwm zoo uas tsis yog-natural amino acid tsev thaiv, ua si lub luag haujlwm tseem ceeb hauv kev tsim kho tshuaj peptide chemistry thiab bioconju. Nws cov qauv tseem ceeb, -aminoadipic acid, muab cov pob txha bicarboxylate tshwj xeeb, txhawb nqa nws txoj haujlwm tshaj li cov tshuaj proteinogenic amino acids. Nws ua haujlwm raws li "ntau yam khoom siv platform" rau kev qhia cov tshuaj lom neeg hloov pauv thiab muaj peev xwm sib txuas rau peptide molecules.
Tus qauv tsim ntawm cov molecule no siv lub tswv yim kev tiv thaiv classic orthogonal. Cov -amino pawg muaj kev tiv thaiv los ntawm Fmoc (9- fluorenylmethoxycarbonyl) moiety, ua kom muaj kev tshem tawm los ntawm cov mob me me xws li piperidine thaum txhua lub voj voog ntawm cov khoom siv -theem peptide synthesis (SPPS), yog li ua kom yooj yim qhia thiab siv tau zoo peptide saw txuas ntxiv. Lub caij no, cov pab pawg carboxyl ntxiv rau ntawm cov saw hlau sab yog tiv thaiv los ntawm OtBu (tert-butyl) pawg, kom ntseeg tau qhov tsis muaj zog ntawm pawg neeg ua haujlwm tseem ceeb no thoob plaws hauv cov txheej txheem synthesis-tsuas yog tso tawm thaum lub sij hawm kawg muaj zog acid cleavage/deprotection kauj ruam. Qhov kev tsim no tso cai rau cov kws kho mob kom tau txais cov tshuaj polypeptide molecule nrog cov pab pawg dawb sab-chain carboxyl thaum ua tiav cov tshuaj tiv thaiv kab mob, muab qhov chaw zoo tshaj plaws rau kev ua haujlwm tom ntej.
Raws li tus yam ntxwv no, Fmoc-Aad(OtBu)-OH qhia tau tias muaj txiaj ntsig tshwj xeeb hauv kev tsim kho tshiab thiab cov cuab yeej lom neeg. Hauv kev txhim kho cov tshuaj tiv thaiv kab mob - yeeb tshuaj conjugates (ADCs), sab - pawg carboxyl pawg nws qhia ua haujlwm ua cov tshuaj zoo tshaj plaws rau kev sib txuas cov tshuaj tiv thaiv rau lub zog cytotoxic molecules, nteg lub hauv paus rau kev tsim cov khoom ruaj khov thiab homogeneous conjugates. Tsis tas li ntawd, qhov seem no yog ib qho tseem ceeb hauv kev sib txuas ntawm cov peptides ua haujlwm nyuaj, xws li peptide-tshuaj conjugates, peptide-fluorescent probes, thiab PEG- hloov peptides. Nws tuaj yeem siv los sib sau ua ke cov cim npe, ua kom zoo dua cov tshuaj pharmacokinetic, lossis hloov pauv peptide conformation thiab hydrophilicity. Yog li ntawd, nws tsis yog tsuas yog ib chav tsev nyob rau hauv lub peptide saw tab sis ib tug pivotal tshuaj "bridge" uas txhawb peptide-raws li kev kho mob kom ua tiav lub hom phiaj, pom, los yog txhim khu kev ruaj ntseg.

 

 

 

    

pob hauv 1kg / hnab 10kg / thoob 20kg / thoob

 

 

 

 

 

 

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