Z-N-Me-Arg(Pbf)-OH CAS 2135655-88-6

Lub TNN Development Limited yog ib qho ntawm feem txhim khu kev qha manufacturers thiab lwm tus neeg ntawm z-n-me-arg(pbf)-oh cas 2135655-88-6 nyob rau hauv Suav teb. Thov koj xav tias dawb rau cov lag luam wholesale customized z-n-me-arg(pbf)-oh cas 2135655-88-6 ntawm tus nqi qis los ntawm peb lub hoobkas. Yog tias koj muaj lus nug txog cov qauv dawb thiab cov ntaub ntawv luv nqi, thov koj xav email rau peb.

 

 

 

 

 

Z-N-Me-Arg (Pbf) - OH (CAS: 2135655-88-6) yog ib qho kev ua haujlwm siab heev peptide synthesis block. Nws cov qauv molecular complex integrates lub zog alkaline guanidine pab pawg neeg ntawm arginine, lub aromatic nplhaib system hloov los ntawm sulfonyl pab pawg neeg, lub ntsiab saw N-methylation hloov, thiab orthogonal tiv thaiv lub tswv yim, ua rau nws yog ib tug tseem ceeb tshuaj cuab yeej rau tsim enzyme inhibitors thiab tsom cov tshuaj kho. Cov molecule no tiv thaiv cov - amino pawg los ntawm benzyloxycarbonyl (Z / Cbz), txhim khu kev ruaj ntseg metabolic los ntawm cov saw tseem ceeb N-methylation, thiab tiv thaiv cov guanidine sab saw nrog Pbf pawg, ua tiav ntau theem meej tswj cov chaw tshuaj tiv thaiv.
Tus nqi tseem ceeb ntawm qhov thaiv no nyob hauv 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl functional module qhia los ntawm nws cov saw hlau sab. Cov qauv no tsis yog tsuas yog muab cov yam ntxwv tseem ceeb steric hindrance thiab polarity nta, tab sis kuj yog feem ntau siv nyob rau hauv lub pharmacophore tsim ntawm npaum enzyme inhibitors, qhov twg cov hydrogen bonds tseem ceeb thiab electrostatic kev sib cuam tshuam ntawm cov sulfonyl pawg thiab lub active site ntawm lub hom phiaj enzyme. Nws (S) - kev teeb tsa ua kom chiral xaiv rau kev khi rau cov hom phiaj lom neeg, thaum pab pawg neeg guanidine tuaj yeem ua lub zog hydrogen nyiaj pub dawb / txais tom qab kev tiv thaiv, ntxiv dag zog rau kev paub txog molecular, tshwj xeeb tshaj yog tsim rau kev tsim cov inhibitors tiv thaiv serine proteases, kinases, lossis HIV proteases.
Hauv kev tsim tshuaj thiab kev siv tshuaj lom neeg lom neeg, cov khoom sib xyaw no nthuav tawm ntau yam kev ua haujlwm zoo. Nws yog ib qho tseem ceeb ntawm cov txheej txheem tsim kho tshiab los tiv thaiv- qog cov kab mob xws li tshuaj tiv thaiv coagulants, tshuaj tiv thaiv kab mob, thiab kinase inhibitors. Hauv cov khoom siv -theem lossis kua-theem peptide synthesis, cov tshuaj pharmacophore complex no tuaj yeem raug muab tso rau hauv cov haujlwm tshwj xeeb ntawm cov saw peptide los tsim peptide inhibitors nrog txhim kho kev sib raug zoo thiab kev xaiv. Tsis tas li ntawd, nws tseem yog ib qho tseem ceeb tshuaj lom neeg soj ntsuam rau kev tsim cov tsev qiv ntawv peptide, tshuaj xyuas cov ligands nquag, thiab kawm txog protein ligand kev sib cuam tshuam cov txheej txheem, ua kom pom nws lub luag haujlwm txuas hauv kev sib txuas hluavtaws chemistry thiab kev tshawb fawb txog kev ua haujlwm lom neeg.

 

 

 

    

pob hauv 1kg / hnab 10kg / thoob 20kg / thoob

 

 

 

 

 

 

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