Txhaum qhov ncauj barriers (1)

Taw qhia rau IL-23

Interleukin-23 (IL-23) yog ib tug tswv cuab ntawm IL-12 cytokine tsev neeg thiab ib tug heterodimeric cytokine muaj li ntawm ob subunits, p19 thiab p40. Nws cov receptor IL-23R yog tsim los ntawm ob lub subunits, IL-23R thiab IL-12R 1. Ntawm lawv, p19 tshwj xeeb khi rau IL-23R, thaum p40 khi rau IL-12R subunits ntawm IL-23 lossis IL-12 (raws li qhia hauv daim duab hauv qab no). Thaum IL-23 khi rau IL-23R, nws ua rau hauv qab phosphorylation ntawm JAK2 thiab TYK2, ua kom muaj kev taw qhia thiab ua rau phosphorylation ntawm STAT proteins, thaum kawg txhawb kev qhia ntawm cytokines xws li IL-17A, IL-17F, IL-22, IL-22 Txoj hauv kev cuam tshuam nrog phosphorylation ntawm ntau yam STAT proteins, tab sis nws cov haujlwm lom neeg feem ntau yog kho los ntawm STAT3

IL-23 tso tawm los ntawm cov hlwb myeloid tom qab cov ntaub so ntswg raug mob ua kom cov lus teb inflammatory los ntawm kev tsav tsheb Th17 / IL-17 signaling axis, uas tau raug lees paub tias yog cov txheej txheem tseem ceeb ntawm psoriasis (PsO) thiab psoriatic mob caj dab (PsA). Targeted IL-23p19 kev kho mob tuaj yeem txhim kho cov tsos mob ntawm daim tawv nqaij thiab sib koom ua ke thiab pab kho lub cev tiv thaiv kab mob. Lub caij no, IL-23 tau qhia ntau heev hauv cov hnyuv mucosal ntawm cov neeg mob uas muaj kab mob ulcerative colitis (UC) thiab Crohn tus kab mob (CD). Los ntawm kev ua kom Th17 hlwb thiab lwm lub cev tiv thaiv kab mob, nws txhawb kev tso tawm cov cytokines pro-inflammatory cytokines xws li IL-17A, IL-17F, thiab IL-22, ua rau cov kab mob plab hnyuv loj ntxiv (xws li ua rau cov kab mob hauv plab hnyuv thiab cuam tshuam kev ncaj ncees ntawm txoj hnyuv). Yog li ntawd, kab mob plab hnyuv (IBD) kuj tau dhau los ua qhov tseem ceeb muaj peev xwm qhia tau rau lub hom phiaj IL-23 qhia txoj kev kho.